Question: Local folding of a protein occurs at what defined level of protein folding?
Answer Choices:
Primary
Secondary
Tertiary
Quaternary
All of the above
Answer: Secondary
Question: Which of the following molecules are weak acids?
Answer Choices:
HCl
CH3⁻
HNO3
HCO3⁻
Both B and D
Answer: Both B and D
Question: What was the name of the amino acid that the author was investigating in the DiNardo paper?
Answer Choices:
Leucine
Proline
Cysteine
Alanine
Aspartate
Answer: Cysteine
Question: Which of the following weak interactions would require the least amount of energy to disrupt?
Answer Choices:
hydrogen bonds
ionic bonds
van der Waals interactions
disulfide bonds
Answer: van der Waals interactions
Question: Enzymes are biological catalysts that enhance the rate of a reaction by:
Answer Choices:
decreasing the activation energy
decreasing the amount of free energy released
increasing the activation energy
increasing the amount of free energy released
increasing the energy of the transition state
Answer: decreasing the activation energy
Question: What reason did the author suggest for omeprazole having a higher pKa than androstenodione when binding compared to androstenedione?
Answer Choices:
The Km was different between them
There were additional hydrophobic contacts made
The Km and Kd were different between them
Their Kcat were different
None of the above
Answer: There were additional hydrophobic contacts made
Question: The three-dimensional structure of a protein is determined primarily by:
Answer Choices:
electrostatic guidance from nucleic acid structure
how many amino acids are in the protein
hydrophobic interactions with lipids that provide a folding framework
modification during interaction with ribosomes
the sequence of amino acids in the protein
Answer: the sequence of amino acids in the protein
Question: Which of the following is a hydronium ion?
Answer Choices:
H3O+
OH⁻
HCO3⁻
HOCH3
H2O+
Answer: H3O+
Question: The following amino acid would stabilize the tertiary level of protein folding through which interaction?
Answer Choices:
disulfide bond
peptide bond
hydrogen bond
ionic bond
Answer: disulfide bond
Question: Which of the following is an example of posttranslational modification of proteins?
Answer Choices:
Phosphorylation
Acetylation
Proteolytic Cleavage
Glycosylation
All of the above are examples of posttranslational modification
Answer: All of the above are examples of posttranslational modification
Question: Salt bridges in proteins are an example of __________.
Answer Choices:
Hydrogen bonds
Ionic interactions
Hydrophobic interactions
van der Waals forces
London dispersion forces
Answer: Ionic interactions
Question: What is a common role of a coenzyme in a reaction as stated in class?
Answer Choices:
To lower the activation energy of a reaction further
The donation of atoms to a reaction
To alter the enzyme’s shape
To assist the substrate by binding to the enzyme, enabling substrate to active site engagement
Answer: The donation of atoms to a reaction
Question: The enzyme fumarase catalyzes the reversible hydration of fumaric acid to L-malate, but it will not catalyze the hydration of maleic acid, the cis isomer of fumaric acid. This is an example of:
Answer Choices:
biological activity
chiral catalysis
racemization
stereospecificity
stereoselectivity
Answer: stereospecificity