Question: Which of the following agents is preferred in women receiving tamoxifen therapy because it is not a strong inhibitor of CYP2D6?
Answer Choices:\n\nA. Fluoxetine (Prozac®) B. Paroxetine (Paxil®) C. Bupropion (Wellbutrin®) D. Citalopram (Celexa®)
Answer:\nD. Citalopram (Celexa®)
Question: The effectiveness for preventing unintended pregnancy with use of OTC Plan B One-Step® is most likely to be highest for which of the following patients?
Answer Choices:\n\nA. A 21-year-old obese woman who experienced a barrier-method failure during intercourse 18 hours ago B. A 16-year-old woman who experienced a condom breakage with her partner 12 hours ago C. A 17-year-old woman requesting Plan B One-Step® 4 days (96 hours) after unprotected intercourse D. A 33-year-old woman presenting to the pharmacy 36 hours after unprotected intercourse
Answer:\nB. A 16-year-old woman who experienced a condom breakage with her partner 12 hours ago
Question: Which of the following medications is a selective estrogen receptor modulator (SERM) used in osteoporosis prevention and treatment?
Answer Choices:\n\nA. Teriparatide (Forteo®) B. Raloxifene (Evista®) C. Denosumab (Prolia®) D. Calcitonin
Answer:\nB. Raloxifene (Evista®)
Question: A 30-year-old woman with elevated blood pressure is planning to become pregnant within the next 1–2 years. In the meantime, she would like to use a short-term contraceptive. Which contraceptive method is most appropriate for this patient?
Answer Choices:\n\nA. Camila® (oral norethindrone 0.35 mg tablets) B. Jolessa® (oral ethinyl estradiol / levonorgestrel) C. ParaGard® intrauterine device (IUD) D. Diaphragm
Answer:\nA. Camila® (oral norethindrone 0.35 mg tablets)
Question: During which uterine stage would you expect uterine prostaglandin levels to be highest?
Answer Choices:\n\nA. Ovulation B. Secretory phase C. Proliferative phase D. Menses
Answer:\nD. Menses
Question: Which contraceptive is most appropriate for a 37-year-old woman who smokes 10 cigarettes daily and has a history of missed medical appointments?
Answer Choices:\n\nA. Depo-Provera® (depot medroxyprogesterone acetate) B. Skyla® (levonorgestrel intrauterine system) C. Twirla® (transdermal combined hormonal contraceptive) D. Mircette® (oral ethinyl estradiol/desogestrel tablets)
Answer:\nA. Depo-Provera® (depot medroxyprogesterone acetate)
Question: Which vitamin is necessary for calcium absorption and bone health, particularly in osteoporosis management?
Answer Choices:\n\nA. Vitamin A B. Vitamin B12 C. Vitamin C D. Vitamin D
Answer:\nD. Vitamin D
Question: Which of the following best describes the mechanism of action of alendronate (Fosamax®)?
Answer Choices:\n\nA. Increases calcium absorption from the GI tract B. Stimulates osteoblast activity C. Inhibits osteoclast-mediated bone resorption D. Inhibits osteoblast-mediated bone formation
Answer:\nC. Inhibits osteoclast-mediated bone resorption
Question: Which osteoporosis medication is administered subcutaneously every 6 months?
Answer Choices:\n\nA. Alendronate B. Risedronate C. Denosumab (Prolia®) D. Teriparatide (Forteo®)
Answer:\nC. Denosumab (Prolia®)
Question: Which of the following medications is approved for the prevention, but not treatment, of postmenopausal osteoporosis?
Answer Choices:\n\nA. Conjugated estrogens/bazedoxifene (Duavee®) B. Teriparatide (Forteo®) C. Alendronate (Fosamax®) D. Raloxifene (Evista®)
Answer:\nA. Conjugated estrogens/bazedoxifene (Duavee®)
Question: What is the most appropriate calcium intake recommendation for a 70-year-old woman with osteoporosis?
Answer Choices:\n\nA. 500 mg/day B. 800 mg/day C. 1000 mg/day D. 1200 mg/day
Answer:\nD. 1200 mg/day
Question: The following figure best describes the mechanism of action of which medication for osteoporosis? (Visual showing osteoclast apoptosis and inhibition of differentiation)
Answer Choices:\n\nA. Teriparatide (Forteo®) B. Romosozumab (Evenity®) C. Denosumab (Prolia®) D. Alendronate (Fosamax®)
Answer:\nC. Denosumab (Prolia®)
Question: Which of the following represent(s) an indication for hormone therapy in a peri/postmenopausal woman? SELECT ALL THAT APPLY
Answer Choices:\n\nA. Frequent hot flushes that affect quality of life and sleep B. Prevention of endometrial cancer C. Frequent hot flushes that do not impact normal daily functioning D. Prevention of postmenopausal osteoporosis
Answer:\nA. Frequent hot flushes that affect quality of life and sleep, D. Prevention of postmenopausal osteoporosis
Question: The primary mechanism of anthracycline mediated cytotoxicity is its:
Answer Choices:\n\nA. Prevention of dimerization of HER2 receptors B. Initiation of CD8 T cell killing C. Inhibition of microtubule disassembly D. Intercalation into DNA and inhibition of topoisomerase II
Answer:\nD. Intercalation into DNA and inhibition of topoisomerase II
Question: NR is a 45-year-old premenopausal female with ductal carcinoma in situ (stage 0) that is ER+, PR+, HER2-. What is the most appropriate treatment recommendation for NR?
Answer Choices:\n\nA. Surgery followed by adjuvant raloxifene (Evista®) B. Surgery followed by adjuvant doxorubicin (Adriamycin®) C. Surgery followed by adjuvant radiation therapy D. Surgery followed by adjuvant tamoxifen (Nolvadex®)
Answer:\nD. Surgery followed by adjuvant tamoxifen (Nolvadex®)
Question: Which of the following is most likely to occur in a woman with a diagnosis of osteoporosis?
Answer Choices:\n\nA. Hip fracture without alendronate (Fosamax®) B. Atypical femur fracture with zoledronic acid (Reclast®) C. Osteonecrosis of the jaw with ibandronate (Boniva®) D. Flu-like symptoms with risedronate (Actonel®)
Answer:\nB. Atypical femur fracture with zoledronic acid (Reclast®)
Question: KJ is a 62-year-old man with a T-score of -2.7 after a fall and femoral fracture. What is the most appropriate treatment?
Answer Choices:\n\nA. Raloxifene (Evista®) B. Abaloparatide (Tymlos®) C. Alendronate (Fosamax®) D. Romosozumab (Evenity®)
Answer:\nD. Romosozumab (Evenity®)